Outcome of acute myeloid leukemia with recurrent cytogenetic abnormalities; A retrospective study in South Egypt Cancer Institute Rania Bakry;1AsmaaOmar,2Abeer M. Darwish,3Rania Hafez,4Safinaz Hussein,5Alaa Salah6

doi:10.21608/secioj.2018.10596

Outcome of acute myeloid leukemia with recurrent cytogenetic abnormalities; A retrospective study in South Egypt Cancer Institute Rania Bakry;1AsmaaOmar,2Abeer M. Darwish,3Rania Hafez,4Safinaz Hussein,5Alaa Salah6

10.21608/secioj.2018.10596

Abstract

Acute myeloid leukemia (AML) is one of the world health problems especially in developing
countries, as the majority of patients die in spite of the progress in therapy and supportive care. The
response to therapy and the overall survival of AML patients depended on several risk factors.
Materials and Methods: Cytogenetic analysis was performed using Fluorescent In Situ
Hybridization (FISH) analysis for 147 AML patients to detect the outcome and the overall survival of
AML with certain cytogenetic abnormalities (t (15;17), t (8;21) and Inv 16).
Results:147 patients were classified as follow: 33 were AML M2, 53 were AML M3 and 61
were AML M4/M5. Cytogenetic analysis revealed that t (15,17) was positive in all AML M3 cases
(53/53), t (8,21) was positive in 28/33 of AML M2 cases while inv 16 was positive in 23/61 of AML
M4/M5 cases. Patients with t (15;17) or t (8;21) were associated with good prognosis and better
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outcome. WBCs count below 30x10 /L and age less than 60 years old had good prognostic impact on
overall survival (OS) in AML.
Conclusion: t (15; 17) and t (8; 21) in AML were associated with good prognosis and better outcome
in combination with other factors. The low WBCs count and the age of patients at presentation had
good prognostic impact on overall survival(OS).

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