Standard versus Modified FOLFIRINOX Protocols in Patients with Metastatic Pancreatic Carcinoma: Efficacy versus Toxicity
Abstract
Background: FOLFIRINOX revolutionized the management of patients with metastatic pancreatic adenocarcinoma (MPA). However, studies have shown severe toxicity profile leading to its limitation as a standard of care protocol. Aim: Comparison between standard and modified FOLFIRINOX in terms of response rate (RR) and toxicity profile among patients with MPA. Methods: We reviewed the medical records of 34 patients diagnosed with MPA, they were divided into two groups: standard FOLFIRINOX or modified FOLFIRINOX in the first line setting. Results: We observed no statistically significant differences in terms of response rate between the two treatment arms 30% in the standard arm and 28.6 % in the modified arm respectively. the toxicity profile was slightly better in the modified arm, namely, dose reductions14.2% vs 40 % favoring modified arm, treatment delay 28.5 % vs 50 % in the standard arm and toxicity mandating hospitalization 21.4 % vs 30 % also favoring modified arm, however this didn’t reach statistically significant difference. Conclusion: Modified FOLFIRINOX presents comparable activity compared to standard FOLFIRINOX in MPA in terms of response rate and toxicity profile favoring the modified protocol.
(2024). Standard versus Modified FOLFIRINOX Protocols in Patients with Metastatic Pancreatic Carcinoma: Efficacy versus Toxicity. SECI Oncology Journal, 12(2), 122-125.
MLA
. "Standard versus Modified FOLFIRINOX Protocols in Patients with Metastatic Pancreatic Carcinoma: Efficacy versus Toxicity". SECI Oncology Journal, 12, 2, 2024, 122-125.
HARVARD
(2024). 'Standard versus Modified FOLFIRINOX Protocols in Patients with Metastatic Pancreatic Carcinoma: Efficacy versus Toxicity', SECI Oncology Journal, 12(2), pp. 122-125.
VANCOUVER
Standard versus Modified FOLFIRINOX Protocols in Patients with Metastatic Pancreatic Carcinoma: Efficacy versus Toxicity. SECI Oncology Journal, 2024; 12(2): 122-125.