Clinico-pathological and Epidemiological Characteristics of Colorectal Cancer Patients - Retrospective Study

Objective: Our aim of this study was analysis of the clinic epidemiological 
patterns of colorectal cancer (CRC) in patients presented at clinical oncology 
department in Assiut university hospitals from 2010 to 2020
Methods: This study included 263 patients with CRC who fulfilled the 
following criteria: age > 18 years, proven by histopathology, patients with all 
stages of CRC were included. Data analyses were performed using statistical 
package for the social science (IBM-SPSS) version 26.0 software. Qualitative 
data were expressed as frequency and percentage. Mean ± SD was used to 
express the numerical variables.
Results: The mean age of the enrolled patients was 45.88±15.23 years. The 
incidence was higher in males, accounting for 141 cases (53.6%). the majority, 
comprising 151 (57.4%), individuals were diagnosed with cancer rectum 66 
(25.1%). The most common presenting symptom was constipation 121 (46.0%). 
The predominant subtype was adenocarcinoma, observed in 186 (70.7%) 
patients. As for TNM staging the distribution of "T" stages revealed 133 
(50.6%) patients at "T3" followed by 65 (24.7%) patients at "T4". Concerning 
metastasis, 93 (35.4%) patients were diagnosed with synchronous metastasis 
"M1", while 170 (64.6%) patients were categorized as "M0" Relapse, either 
distant or local, occurred in 42 (16.0%) patients. Distant relapse was observed in 
33 (12.5%) patients. Local relapse occurred in 17 (6.5%) patients. 
Conclusion: CRC mostly presented at advanced stages so analysis of its risk 
factors needs further studies to understand its behavior and early detection carry 
hope for improving its survival.